We are educated to regard uncertainty as a problem to be resolved or a source of anxiety. Regardless of how much apparent order we seem to create, the future can still worry us and deprive us of inner peace.
Appreciating uncertainty, not as a problem to be resolved but as the nature of things, removes this inherent worry and anxiety.
Since we do not know how things really work, including our bodies, our minds and this world, uncertainty is just the nature of how things are. The central characteristic of the so-called future is that it is unknown, therefore uncertain.
As we become accustomed to the fact that we neither know nor do not know the future, or for that matter the past and present, even though we might imagine we do, uncertainty becomes for us an integral part of nature and we can relax. Life becomes an adventure, a game. There is in fact nothing to know. That is all.